Measures of Motor Function

Measures of motor function used in the SPINRAZA clinical studies.¹

Hammersmith Infant Neurological Examination (HINE) Section 2

A measure of the achievement of motor milestones, consisting of 8 milestone categories.²

Hammersmith Functional Motor Scale−Expanded (HFMSE)

A measure to assess motor function, providing objective information on motor ability and clinical progression.³

World Health Organization (WHO) Motor Milestones (Multicentre Growth Reference Study Group)

A set of 6 major motor milestones that are expected to be attained by 24 months of age in healthy children.^4,5

Children’s Hospital of Philadelphia Infant Test of Neuromuscular Disorders (CHOP INTEND)

A 64-point motor assessment designed to evaluate muscle strength and function in infants with SMA.^6,7

6-Minute Walk Test (6MWT)

An evaluation of the distance a person can walk quickly in 6 minutes.⁸

Upper Limb Module (ULM)

Designed to assess upper limb function in nonambulatory individuals, consisting of 9 upper limb performance items reflective of activities of daily living.^9,10

Revised Upper Limb Module (RULM)

Designed to assess upper limb function in patients with SMA; it consists of 20 items for a maximum total score of 37.¹¹

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References

SPINRAZA Summary of Product Characteristics. Biogen.
Haataja L, Mercuri E, Regev R. Optimality score for the neurologic examination of the infant at 12 and 18 months of age. J Pediatr . 1999; 135(2 pt 1):153-161.
PNCR Network for SMA. Expanded Hammersmith Functional Motor Scale for SMA (HFMSE). Accessed February 4, 2022.
Wijnhoven TM, de Onis M, Onyango AW, et al. Assessment of gross motor development in the WHO Multicentre Growth Reference study. Food Nutr Bull . 2004;25(suppl 1):S37-S45.
WHO Multicentre Growth Reference Study Group. WHO motor development study: windows of achievement for six gross motor development milestones. Acta Paediatr Suppl . 2006;450:86-95.
Glanzman AM, Mazzone E, Main M, et al. The Children’s Hospital of Philadelphia Infant Test of Neuromuscular Disorders (CHOP INTEND): test development and reliability. Neuromuscul Disord. 2010;20(3):155-161.
Spinal Muscular Atrophy Clinical Research Center. CHOP INTEND for SMA Type I score sheet. Updated March 14, 2013. Accessed April 26, 2016.
Montes J, Dunaway S, Montgomery MJ, et al. Fatigue leads to gait changes in spinal muscular atrophy. Muscle Nerve . 2011;43(4):485-488.
Mazzone E, Bianco F, Martinelli D, et al. Assessing upper limb function in nonambulant SMA patients: development of a new module. Neuromuscul Disord . 2011;21(6):406-412.
Sivo S, Mazzone E, De Sanctis, et al. Upper limb module in non-ambulant patients with spinal muscular atrophy: 12 month changes. Neuromuscul Disord . 2015;25(3):212-215.
Mazzone ES, Mayhew A, Montes J, et al. Revised Upper Limb Module for spinal muscular atrophy: development of a new module. Muscle Nerve . 2016. doi:10.1002/mus.25430.

Adverse events should be reported to medinfohongkong@biogen.com. Additional information can be found in the package leaflet.

Biogen-176301-HKG-09/2022

Measures of Motor Function

Measures of motor function used in the SPINRAZA clinical studies.1

Measures of motor function used in the SPINRAZA clinical studies.¹